We are doing this research to determine if drugs or food supplements could reduce occurrence of bowel polyps, which in turn could reduce bowel cancer risk.

There are two parts to this clinical trial. The first part is the main trial assessing the efficacy of aspirin or aspirin plus metformin, and the second part is the resveratrol sub-trial.

The second part of the trial will test two doses of resveratrol against a placebo. Patients will be able to participate if they are unable to take part in the main trial; already taking aspirin or metformin, unable to take aspirin or do not want to take aspirin and metformin.